Built in the late 19th century, the presidential residence was originally intended to be used as the residence of Prince Constantine. Constructed on land donated by the Greek state, its design was based on plans by Ziller, who wanted to recreate the style of the luxurious neoclassical residences in Athens at the time.

The stunning three-storey mansion suffered severe fire damage in 1909, and the refurbished building was named the New Palace in 1913, following the coronation of King Constantine. Since then, the building has been home to kings and presidents of the republic.

Since the restoration of democracy in Greece in 1974, the mansion has been used as the residence of the President of the Hellenic Republic. Only two additions have been made to the original building, namely a large ballroom and the current reception hall, added in the 1960s.